• Provides 100 mcg per serving of Vitamin K2 as Menaquinone-7 (MK-7)
• MK-7 has the longest half-life of all Vitamin K forms, as well as the best extra-hepatic distribution
• Vitamin K2, particularly MK-7, allows for a much lower dosage with significant clinical benefit
• Derived from natto beans, the richest natural food-based MK-7
• Suitable for vegetarians/vegans

The discovery of Vitamin K-dependent post-translational modifications (VKDs) of proteins involved not only in coagulation but also in bone metabolism, vascular calcification, cell growth regulation, and even ATP production has radically changed the physiological and clinical importance of this enzymatic cofactor. VKD cofactor proteins are found almost ubiquitously in various cell types, and modification by γ-carboxylation is necessary for biological activity. Dietary intake of Vitamin K is often insufficient, and Vitamin K is diverted to enzymes essential for short-term survival (e.g., coagulation), leading to suboptimal carboxylation of proteins associated with aging and chronic diseases, such as matrix Gla protein, osteocalcin, and gas6.

Clinically, lower Vitamin K intake has been linked to a higher risk of myocardial infarction and stroke, dental plaque instability, and more recently, diabetes. Higher Vitamin K intake, particularly K2, has been associated with lower all-cause mortality, coronary heart disease, aortic calcification, as well as cancer incidence and mortality. Higher intake of MK-7, which has the longest half-life and the most significant extra-hepatic distribution, has been associated with a lower risk of fracture and greater BMD.