• Provides clinically effective doses of vitamins D and K per capsule
• Vitamin D3 is the most potent for increasing serum and storage levels of vitamin D.
• Uses the optimal form of vitamin K, vitamin K2 menaquinone-7 (MK-7)
• MK-7 has the longest half-life and best extra-hepatic distribution of all forms
• A combination of D3 and MK-7 shows a synergistic advantage over single-nutrient therapy

Vitamin D and vitamin K have diverse and complementary physiological functions, close associations with chronic and age-related diseases, and a strong body of clinical evidence documenting widespread insufficiency and therapeutic potential. Vitamin D has both hormonal and non-hormonal functions, with vitamin D receptors translating into myriad physiological actions, ranging from bone metabolism to modulation of immune activity.

Vitamin D regulates the expression of hundreds of genes, influences cell proliferation and signaling, insulin production and sensitivity, and is an essential inhibitor of several inflammatory pathways. Insufficiency has been associated with increased cardiovascular disease, cancer risk, diabetes and metabolic syndrome, as well as overall mortality.

Vitamin K-dependent proteins (VKDPs) are also nearly ubiquitous and regulate various functions, including cell growth, arterial calcification, and bone metabolism.12 Clinically, low intakes are associated with an increased risk of cardiovascular disease, diabetes, cancer, fractures, and all-cause mortality. Vitamins K and D have complementary physiological functions, and clinical trials have shown synergistic benefits for osteoporosis and cardiovascular disease when used together.