NMN

• Provides 150 mg of Nicotinamide Mononucleotide (NMN) per serving, which clinical trials have shown to increase blood NAD+ levels.
  
• NMN is the immediate precursor to NAD+ and bridges the decline in age-related NAD+ levels.
  
• NAD+ is an essential coenzyme for many pathways related to energy production, mitochondrial health, and DNA repair, and its decline is strongly associated with aging.
  
• Vegetarian capsules with a clinically established dosage

NMN is a bioavailable precursor to Nicotinamide Adenine Dinucleotide (NAD+), a key coenzyme required for over 500 enzymatic reactions. As many of these enzymatic reactions are related to cellular metabolism, aging, inflammation, circadian rhythm, mitochondrial respiration, glycolysis, and DNA repair, NAD+ is considered essential for human health and longevity. NAD+ is also required for the expression of sirtuins, enzymes with numerous cellular regulatory effects particularly important for inflammation, DNA repair, and energy metabolism. Much research shows that aging leads to a decrease in NAD+ and sirtuin expression, which leads to impaired mitochondrial function and biogenesis and increased oxidative damage, drivers of the aging process itself as well as many age-related diseases, including cardiovascular and metabolic diseases.

Controlled clinical trials have demonstrated the multiple benefits of NMN supplementation, including improved insulin sensitivity and signaling in women with glucose metabolism disorders, as well as aerobic capacity in healthy runners.6-8 To illustrate its potential to act on aging pathways by restoring NAD+ levels, NMN supplementation for 12 weeks showed a trend toward reduced arterial stiffness, an independent risk factor related to aging for cardiovascular and metabolic diseases.

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