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  Natural Eggshell Membrane (NEM®) has been clinically proven to reduce joint pain and stiffness due to osteoarthritis.

  
  


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  It is clinically proven to reduce pain and stiffness resulting from moderate-intensity aerobic exercise.

  
  


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  Improved pain, stiffness, and flexibility within days of use.

  
  


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  NEM provides numerous joint nutrients, including glucosamine, chondroitin, and type I collagen.
  One vegetarian NEM capsule per day is the clinically proven dose.

  
  

Numerous clinical trials have shown NEM to reduce joint pain and stiffness associated with osteoarthritis, as well as joint pain and stiffness caused by moderate-intensity aerobic exercise. NEM is composed of eggshell membrane (shell-free), a natural source of glycosaminoglycans found in cartilage, including dermatan sulfate and chondroitin sulfate, hexosamines such as glucosamine, as well as hyaluronic acid and type I collagen. In vitro and in vivo studies indicate that NEM possesses multiple mechanisms of action, including the inhibition of several pro-inflammatory cytokines associated with joint inflammation, such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α).

In a randomized, double-blind, placebo-controlled trial, NEM was shown to rapidly reduce exercise-induced pain, stiffness, and discomfort in healthy, postmenopausal women. It was also shown to reduce urinary levels of type II collagen cross-linked C-telopeptide (CTX-II), a biomarker of cartilage degradation, in both healthy individuals and those with joint disease. Furthermore, controlled clinical trials have demonstrated a reduction in joint pain and stiffness in individuals with knee osteoarthritis within 10 days of NEM use. Open-label trials have shown sustained improvements in pain and flexibility for multiple joint and connective tissue disorders within one week.