EstroVantage EM™

• Offers a full range of protective compounds from cruciferous vegetables, including I3C, DIM, and sulforaphane.
• Provides a unique blend of botanicals that enhance estrogen metabolism, shifting away from carcinogenic metabolites.
• Promotes the detoxification of a variety of environmental toxins as well as naturally produced hormones by enhancing liver phase 1 and phase 2 enzymes.
• Contains botanicals with potent anti-inflammatory activity.
• Suitable for vegetarians/vegans

EstroVantage EM provides a comprehensive formula of plant-derived compounds that enhance the metabolism of estrogen and its metabolites. Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with a reduced incidence of cancer when consumed in greater quantities, most likely by causing a shift in metabolism towards less carcinogenic estrogen metabolites. EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3'-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been associated with lower rates of neoplastic changes and a more favourable estrogen profile. Not only do these glucosinolates enhance estrogen metabolism, but they also reduce inflammation by targeting key signalling molecules, such as Nrf2 and NF-κB.

EstroVantage EM also contains other potent botanical compounds that reduce inflammation and block carcinogenic pathways. Silymarin, a milk thistle extract, downregulates gene products involved in tumour cell proliferation, as well as their invasion, angiogenesis, and metastasis. This unique combination contains green tea polyphenols, lycopene (from tomato extract), turmeric and rosemary extracts, and calcium D-glucarate, all of which have been shown to favourably alter estrogen metabolism and reduce carcinogenic risk. Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula resulted in significantly higher urinary levels of the protective estrogen metabolite 2-OHE1 and lower levels of the more dangerous estrogen metabolite 16α-OHE1 in premenopausal women. Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula resulted in significantly higher urinary levels of the protective estrogen metabolite 2-OHE1 and lower levels of the more dangerous estrogen metabolite 16α-OHE1 in premenopausal women.

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