5-HTP · 100 mg

• Extra-strength 100 mg formula for easy dosing
• Naturally sourced from the seed of the African plant Griffonia simplicifolia
• 5-HTP easily crosses the blood-brain barrier to increase serotonin synthesis in the central nervous system.
• The delayed-release formulation may minimize gastric discomfort and helps prevent the rapid highs and lows associated with immediate-release 5-HTP.

5-HTP (5-hydroxytryptophan) is an amino acid precursor to serotonin, a brain chemical, a neurotransmitter essential for mood balance and the completion of cognitive tasks such as learning and memory formation. Low mood and other conditions have long been associated with low serotonin levels, making 5-HTP an attractive natural option for elevating mood and improving emotional health. Extended-release tablets bypass the limitations of immediate-release formulations. This allows for a sustained increase in serotonin, avoiding the highs, fluctuations, and rapid drops associated with forgetting or delaying a dose. Furthermore, extended-release preparations may help minimize gastric discomfort that some individuals experience with 5-HTP.

Clinical research supports 5-HTP supplementation for mood. A randomized double-blind clinical trial involving 60 patients evaluated the efficacy of 5-HTP supplementation versus fluoxetine. Efficacy was determined by comparing baseline HAM-D scores with those obtained after 2 weeks, 4 weeks, and 8 weeks. Following 5-HTP supplementation, 73% of patients taking 5-HTP and 80% of patients taking fluoxetine showed a significant reduction in HAM-D scores from the second week through the end of the study.

5-HTP has also been used to treat the serotonergic imbalance involved in chronic pain, including migraines, as well as fibromyalgia and insomnia. Individuals with fibromyalgia taking 300-400 mg of 5-HTP per day in divided doses reported improvements in symptoms, including pain intensity, morning stiffness, and insomnia. 5-HTP is known to improve sleep quality, which is essential for individuals with fibromyalgia. In fact, 5-HTP has been shown to promote REM sleep in healthy adults. Increased time spent in REM sleep is one reason why 5-HTP is considered a sleep aid.

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